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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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In conclusion, rutile titanium dioxide is a multifaceted material with a plethora of uses spanning from the cosmetic to the technological sector. Its unique combination of physical characteristics makes it an indispensable component in numerous industrial processes and consumer products. As research continues, new applications for this versatile mineral are likely to emerge, further cementing its status as a cornerstone material in modern industry.

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